Annual report pursuant to Section 13 and 15(d)

Property and equipment (Schedule of Property and Equipment) (Details)

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Property and equipment (Schedule of Property and Equipment) (Details) - USD ($)
12 Months Ended
Dec. 31, 2016
Dec. 31, 2015
Property, Plant and Equipment [Line Items]    
Property and equipment $ 152,456 $ 5,116,533
Less accumulated depreciation 111,323 3,162,037
Total property and equipment, net 41,133 1,954,496
Depreciation expense 4,000 149,000
Land and improvements [Member]    
Property, Plant and Equipment [Line Items]    
Property and equipment 1,107,508
Building [Member]    
Property, Plant and Equipment [Line Items]    
Property and equipment 2,589,231
Building improvements [Member]    
Property, Plant and Equipment [Line Items]    
Property and equipment 253,526
Laboratory equipment [Member]    
Property, Plant and Equipment [Line Items]    
Property and equipment 35,946 848,014
Office and computer equipment [Member]    
Property, Plant and Equipment [Line Items]    
Property and equipment $ 116,510 $ 318,254